Executive Summary
Stem cell research and experimentation has been in process for well over five decades, as stem cells have the unique ability to divide and replicate repeatedly. In addition, their “unspecialized” nature allows them to differentiate into a wide variety of specialized cell types. The possibilities arising from these characteristics has caused great commercial interest, with potential applications ranging from the use of stem cells in reversal or treatment of disease, to targeted cell therapy, tissue regeneration, pharmacological testing on cell-specific tissues, and more. Diseases such as Huntington’s Chorea, Parkinson’s Disease, and spinal cord injuries are examples of clinical applications in which stem cells could offer benefits in halting or even reversing damage.
Traditionally, scientists have worked with both embryonic and adult stem cells as research tools. While the appeal of embryonic cells has been their ability to differentiate into any type of cell, there has been significant ethical, moral and spiritual controversy surrounding their use for research purposes. Although some adult stem cells do have differentiation capacity, it is often limited nature, which creates narrow options for use. Thus, induced pluripotent stem cells represent a promising combination of adult and embryonic stem cell characteristics.
Discovery:
Groundbreaking experimentation in 2006 led to the introduction of induced pluripotent stem cells (iPSC). These are adult cells which are isolated and then transformed into embryonic-like stem cells through the manipulation of gene expression, as well as other methods. Research and experimentation using mouse cells at Kyoto University in Japan was the first instance in which there was successful generation of the iPSC. In 2007, a series of follow-up experiments were done at Kyoto University in Japan in which human adult cells were transformed into iPSC cells.
While there has been continued excitement at the prospect of what such artificially re-manufactured cells could contribute to medical advances, there have also been issues along the way. By 2010, there were a number of private companies that were ready to capitalize on the breakthrough technology that iPSCs represent. One such company, Advanced Cell Technology in Worcester, Massachusetts, discovered several problematic issues while conducting experiments for the purpose of applying for U.S. Food and Drug Administration approval to use iPSC in therapeutic applications. Concerns such as premature cell death, mutation into cancer cells, and low proliferation rates were some of the problems that surfaced.
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Remember, to benefit from this lucrative
product market, you need to anticipate and serve the needs of your clients, or
your competitors will.
Key Findings Include:
•Charts, Timelines, and Financials for the iPSC Research Product Market
•Trends for iPSC Grants, Scientific Publications, and Patents
•5-Year Market Size Projections (2013-2017)
•Competitive Environment Analysis, including Market Share by Competitor
•Preferred Species for iPSC Research
•iPSC Product Categories (Breakdown of Market Share by Each)
•Consumer Behavioral Patterns and Preferred Providers
•Crucial Trends and Unmet Market Needs
•“Tested Sentences” for Selling to iPSC Scientists
•Breakdown of the Marketing Methods Used by Industry Participants
•End-User Survey of iPSC Researchers (181 U.S. / 112 International)
In summary, this is a must-read industry report for research supply companies to optimally position themselves to sell iPSC products. To profit from this lucrative and rapidly expanding market, you need to understand your key strengths relative to the competition, intelligently position your products to fill gaps in the market place, and take advantage crucial iPSC trends. Claim this report now to profit from this expanding market - or your competition will.
Key Findings Include:
•Charts, Timelines, and Financials for the iPSC Research Product Market
•Trends for iPSC Grants, Scientific Publications, and Patents
•5-Year Market Size Projections (2013-2017)
•Competitive Environment Analysis, including Market Share by Competitor
•Preferred Species for iPSC Research
•iPSC Product Categories (Breakdown of Market Share by Each)
•Consumer Behavioral Patterns and Preferred Providers
•Crucial Trends and Unmet Market Needs
•“Tested Sentences” for Selling to iPSC Scientists
•Breakdown of the Marketing Methods Used by Industry Participants
•End-User Survey of iPSC Researchers (181 U.S. / 112 International)
In summary, this is a must-read industry report for research supply companies to optimally position themselves to sell iPSC products. To profit from this lucrative and rapidly expanding market, you need to understand your key strengths relative to the competition, intelligently position your products to fill gaps in the market place, and take advantage crucial iPSC trends. Claim this report now to profit from this expanding market - or your competition will.
I. ABSTRACT
II. BACKGROUND
A. Definition
B. Discovery
C. Advantages & Disadvantages
III. TIMELINE
A. Production of iPSCs (Key Events)
B. Full Timeline of Events
IV. RESEARCH APPLICATIONS
A. Pharmaco-Toxicological Screening
B. Disease Modeling
C. Autologous Cell Transplantation
D. Breakdown of iPSC Research, By Applied Research Application
V. CHARACTERIZATION OF iPSC RESEARCH ADVANCES
A. Methods of Making iPSCs – Comparison of Methods by Downstream Application
B. Summary of iPSC Derivation Methods, by Cell Type
C. Diseases in Which iSPCs Have Been Derived from Patients
VI. COMPANIES SELLING iPSC RESEARCH PRODUCTS
A. List of Companies
B. Rate of Entrants by Year
VII. TYPES OF iPSC RESEARCH PRODUCTS
A. Stem Cell Product Categories
B. iPSC Market Share Breakdown, By Product Area
VIII. COMPANIES DEVELOPING iPSC THERAPIES
A. Commerical Entities
1. ViaCyte
2. Fate Therapeutic
3. iPerian
4. Cellular Dynamics
5. Mesoblast
B. Non-Commercial Organizations Developing iPSC Therapies
IX. STRATEGIC COLLABORATIONS FOR DEVELOPMENT OF iPSC PRODUCTS
A. Life Technologies
B. Lonza Group AG
C. EMD Millipore
D. Sigma Aldrich
E. Roslin Cells, Ltd.
F. ArunA Biomedical
G . CeeTox and Cellular Dynamics
X. MARKET TREND ANALYSIS
A. Clinical Trials
B. Grant Analysis
1. Historical Analysis
2. Future 5-Year Projection
C. Patent Analysis
D. Scientific Publication Analysis
1. Historical Data
2. Future 5-Year Projections
3. Comparison of iPSC Research Frequency, Relative to Other Cell Types
E. Search Phrase Analysis
1. Induced Pluripotent Stem Cell Search Terms
2. Induced Pluripotent Stem Cell “Google” Search Analysis
F. Geographical Analysis: Domestic vs. International Status
1. Number of iPSC Labs, by Region of World
2. Percent of Total iPSC-Specific Research Funding, by Region of World
G. Additional Sources of iPSC Research Funding
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